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Yeast surface display-based identification of ACE2 mutations that modulate SARS-CoV-2 spike binding across multiple mammalian species

Understanding how SARS-CoV-2 interacts with different mammalian angiotensin-converting enzyme II (ACE2) cell entry receptors elucidates determinants of virus transmission and facilitates development of vaccines for humans and animals. Yeast display-based directed evolution identified conserved ACE2...

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Detalhes bibliográficos
Publicado no:bioRxiv
Main Authors: Heinzelman, Pete, Greenhalgh, Jonathan C., Romero, Philip A.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory 2022
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7987019/
https://ncbi.nlm.nih.gov/pubmed/33758860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2021.03.16.435705
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