A metal ion orients mRNA to ensure accurate 2’-O ribosyl methylation of the first nucleotide of the SARS-CoV-2 genome

The SARS-CoV-2 nsp16/nsp10 enzyme complex modifies the 2’-OH of the first transcribed nucleotide of the viral mRNA by covalently attaching a methyl group to it. The 2’-O methylation of the first nucleotide converts the status of mRNA cap from Cap-0 to Cap-1, and thus, helps the virus evade immune su...

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Pubblicato in:bioRxiv
Autori principali: Viswanathan, Thiruselvam, Misra, Anurag, Chan, Siu-Hong, Qi, Shan, Dai, Nan, Arya, Shailee, Martinez-Sobrido, Luis, Gupta, Yogesh K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7987004/
https://ncbi.nlm.nih.gov/pubmed/33758845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2021.03.12.435174
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