Elicitation of broadly protective sarbecovirus immunity by receptor-binding domain nanoparticle vaccines

Understanding the ability of SARS-CoV-2 vaccine-elicited antibodies to neutralize and protect against emerging variants of concern and other sarbecoviruses is key for guiding vaccine development decisions and public health policies. We show that a clinical stage multivalent SARS-CoV-2 receptor-bindi...

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Publicat a:bioRxiv
Autors principals: Walls, Alexandra C., Miranda, Marcos C., Pham, Minh N., Schäfer, Alexandra, Greaney, Allison, Arunachalam, Prabhu S., Navarro, Mary-Jane, Tortorici, M. Alejandra, Rogers, Kenneth, O’Connor, Megan A., Shireff, Lisa, Ferrell, Douglas E., Brunette, Natalie, Kepl, Elizabeth, Bowen, John, Zepeda, Samantha K., Starr, Tyler, Hsieh, Ching-Lin, Fiala, Brooke, Wrenn, Samuel, Pettie, Deleah, Sydeman, Claire, Johnson, Max, Blackstone, Alyssa, Ravichandran, Rashmi, Ogohara, Cassandra, Carter, Lauren, Tilles, Sasha W., Rappuoli, Rino, O’Hagan, Derek T., Van Der Most, Robbert, Van Voorhis, Wesley C., McLellan, Jason S., Kleanthous, Harry, Sheahan, Timothy P., Fuller, Deborah H., Villinger, Francois, Bloom, Jesse, Pulendran, Bali, Baric, Ralph, King, Neil, Veesler, David
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7986998/
https://ncbi.nlm.nih.gov/pubmed/33758839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2021.03.15.435528
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