Site-specific steric control of SARS-CoV-2 spike glycosylation

A central tenet in the design of vaccines is the display of native-like antigens in the elicitation of protective immunity. The abundance of N-linked glycans across the SARS-CoV-2 spike protein is a potential source of heterogeneity between the many different vaccine candidates under investigation....

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Опубликовано в: :bioRxiv
Главные авторы: Allen, Joel D., Chawla, Himanshi, Samsudin, Firdaus, Zuzic, Lorena, Shivgan, Aishwary Tukaram, Watanabe, Yasunori, He, Wan-ting, Callaghan, Sean, Song, Ge, Yong, Peter, Brouwer, Philip J. M., Song, Yutong, Cai, Yongfei, Duyvesteyn, Helen M. E., Malinauskas, Tomas, Kint, Joeri, Pino, Paco, Wurm, Maria J., Frank, Martin, Chen, Bing, Stuart, David I., Sanders, Rogier W., Andrabi, Raiees, Burton, Dennis R., Li, Sai, Bond, Peter J., Crispin, Max
Формат: Artigo
Язык:Inglês
Опубликовано: Cold Spring Harbor Laboratory 2021
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7986994/
https://ncbi.nlm.nih.gov/pubmed/33758835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2021.03.08.433764
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