Site-specific steric control of SARS-CoV-2 spike glycosylation

A central tenet in the design of vaccines is the display of native-like antigens in the elicitation of protective immunity. The abundance of N-linked glycans across the SARS-CoV-2 spike protein is a potential source of heterogeneity between the many different vaccine candidates under investigation....

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Veröffentlicht in:bioRxiv
Hauptverfasser: Allen, Joel D., Chawla, Himanshi, Samsudin, Firdaus, Zuzic, Lorena, Shivgan, Aishwary Tukaram, Watanabe, Yasunori, He, Wan-ting, Callaghan, Sean, Song, Ge, Yong, Peter, Brouwer, Philip J. M., Song, Yutong, Cai, Yongfei, Duyvesteyn, Helen M. E., Malinauskas, Tomas, Kint, Joeri, Pino, Paco, Wurm, Maria J., Frank, Martin, Chen, Bing, Stuart, David I., Sanders, Rogier W., Andrabi, Raiees, Burton, Dennis R., Li, Sai, Bond, Peter J., Crispin, Max
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7986994/
https://ncbi.nlm.nih.gov/pubmed/33758835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2021.03.08.433764
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