Tracking Reactions of Asymmetric Organo‐Osmium Transfer Hydrogenation Catalysts in Cancer Cells

Most metallodrugs are prodrugs that can undergo ligand exchange and redox reactions in biological media. Here we have investigated the cellular stability of the anticancer complex [Os(II)[(η(6)‐p‐cymene)(RR/SS‐MePh‐DPEN)] [1] (MePh‐DPEN=tosyl‐diphenylethylenediamine) which catalyses the enantioselec...

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Detalhes bibliográficos
Publicado no:Angew Chem Int Ed Engl
Main Authors: Bolitho, Elizabeth M., Coverdale, James P. C., Bridgewater, Hannah E., Clarkson, Guy J., Quinn, Paul D., Sanchez‐Cano, Carlos, Sadler, Peter J.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2021
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7985874/
https://ncbi.nlm.nih.gov/pubmed/33590607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202016456
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