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Tracking Reactions of Asymmetric Organo‐Osmium Transfer Hydrogenation Catalysts in Cancer Cells

Most metallodrugs are prodrugs that can undergo ligand exchange and redox reactions in biological media. Here we have investigated the cellular stability of the anticancer complex [Os(II)[(η(6)‐p‐cymene)(RR/SS‐MePh‐DPEN)] [1] (MePh‐DPEN=tosyl‐diphenylethylenediamine) which catalyses the enantioselec...

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Dettagli Bibliografici
Pubblicato in:Angew Chem Int Ed Engl
Autori principali: Bolitho, Elizabeth M., Coverdale, James P. C., Bridgewater, Hannah E., Clarkson, Guy J., Quinn, Paul D., Sanchez‐Cano, Carlos, Sadler, Peter J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2021
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7985874/
https://ncbi.nlm.nih.gov/pubmed/33590607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202016456
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