Tracking Reactions of Asymmetric Organo‐Osmium Transfer Hydrogenation Catalysts in Cancer Cells

Most metallodrugs are prodrugs that can undergo ligand exchange and redox reactions in biological media. Here we have investigated the cellular stability of the anticancer complex [Os(II)[(η(6)‐p‐cymene)(RR/SS‐MePh‐DPEN)] [1] (MePh‐DPEN=tosyl‐diphenylethylenediamine) which catalyses the enantioselec...

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Vydáno v:Angew Chem Int Ed Engl
Hlavní autoři: Bolitho, Elizabeth M., Coverdale, James P. C., Bridgewater, Hannah E., Clarkson, Guy J., Quinn, Paul D., Sanchez‐Cano, Carlos, Sadler, Peter J.
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2021
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7985874/
https://ncbi.nlm.nih.gov/pubmed/33590607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202016456
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