Age-related changes in polycomb gene regulation disrupt lineage fidelity in intestinal stem cells

Tissue homeostasis requires long-term lineage fidelity of somatic stem cells. Whether and how age-related changes in somatic stem cells impact the faithful execution of lineage decisions remains largely unknown. Here, we address this question using genome-wide chromatin accessibility and transcripto...

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Vydáno v:eLife
Hlavní autoři: Tauc, Helen M, Rodriguez-Fernandez, Imilce A, Hackney, Jason A, Pawlak, Michal, Ronnen Oron, Tal, Korzelius, Jerome, Moussa, Hagar F, Chaudhuri, Subhra, Modrusan, Zora, Edgar, Bruce A, Jasper, Heinrich
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2021
Témata:
Genetics and Genomics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7984841/
https://ncbi.nlm.nih.gov/pubmed/33724181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.62250
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