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Hypothesis: Tau pathology is an initiating factor in sporadic Alzheimer's disease

The etiology of the common, sporadic form of Alzheimer's disease (sAD) is unknown. We hypothesize that tau pathology within select projection neurons with susceptible microenvironments can initiate sAD. This postulate rests on extensive data demonstrating that in human brains tau pathology appe...

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Bibliografiske detaljer
Udgivet i:Alzheimers Dement
Main Authors: Arnsten, Amy F. T., Datta, Dibyadeep, Tredici, Kelly Del, Braak, Heiko
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7983919/
https://ncbi.nlm.nih.gov/pubmed/33075193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/alz.12192
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