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Hypothesis: Tau pathology is an initiating factor in sporadic Alzheimer's disease

The etiology of the common, sporadic form of Alzheimer's disease (sAD) is unknown. We hypothesize that tau pathology within select projection neurons with susceptible microenvironments can initiate sAD. This postulate rests on extensive data demonstrating that in human brains tau pathology appe...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Alzheimers Dement
Prif Awduron: Arnsten, Amy F. T., Datta, Dibyadeep, Tredici, Kelly Del, Braak, Heiko
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: John Wiley and Sons Inc. 2020
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7983919/
https://ncbi.nlm.nih.gov/pubmed/33075193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/alz.12192
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