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Prevention of acquired sensorineural hearing loss in mice by in vivo Htra2 gene editing

BACKGROUND: Aging, noise, infection, and ototoxic drugs are the major causes of human acquired sensorineural hearing loss, but treatment options are limited. CRISPR/Cas9 technology has tremendous potential to become a new therapeutic modality for acquired non-inherited sensorineural hearing loss. He...

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Bibliographische Detailangaben
Veröffentlicht in:Genome Biol
Hauptverfasser: Gu, Xi, Wang, Daqi, Xu, Zhijiao, Wang, Jinghan, Guo, Luo, Chai, Renjie, Li, Genglin, Shu, Yilai, Li, Huawei
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2021
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7983387/
https://ncbi.nlm.nih.gov/pubmed/33752742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-021-02311-4
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