Specific knockdown of Htra2 by CRISPR-CasRx prevents acquired sensorineural hearing loss in mice

CasRx, a recently discovered member of the type VI CRISPR system with minimum size, offers a new approach for RNA manipulation with high efficiency and specificity in prokaryotes and eukaryotes. However, in vivo studies of functional recovery using the CasRx system have not been well characterized....

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Main Authors: Yang Guo, Lei Han, Shuang Han, Honghai Tang, Shengyi Wang, Chong Cui, Bing Chen, Huawei Li, Yilai Shu
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2022-06-01
Series:Molecular Therapy: Nucleic Acids
Assuntos:
RNA editing
AAV delivery
CRISPR-CasRx
Htra2
aminoglycosides
acquired sensorineural hearing loss
Acceso en liña:http://www.sciencedirect.com/science/article/pii/S2162253122000907
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