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NTRK2 Fusion driven pediatric glioblastoma: Identification of oncogenic Drivers via integrative Genome and transcriptome profiling

This is the first report of a NACC2‐NTRK2 fusion in a histological glioblastoma. Oncogenomic analysis revealed this actionable fusion oncogene in a pediatric cerebellar glioblastoma, which would not have been identified through routine diagnostics, demonstrating the value of clinical genome profilin...

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Détails bibliographiques
Publié dans:Clin Case Rep
Auteurs principaux: Britton, Heidi M., Levine, Adrian B., Shen, Yaoqing, Mungall, Karen, Serrano, Jonathan, Snuderl, Matija, Pleasance, Erin, Jones, Steven J. M., Laskin, Janessa, Marra, Marco A., Rassekh, Shahrad R., Deyell, Rebecca, Yip, Stephen, Cheng, Sylvia, Dunham, Chris
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2021
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7981675/
https://ncbi.nlm.nih.gov/pubmed/33768871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ccr3.3804
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