MUC4 enhances gemcitabine resistance and malignant behaviour in pancreatic cancer cells expressing cancer-associated short O-glycans

Pancreatic ductal adenocarcinoma (PDAC) is highly lethal. MUC4 (mucin4) is a heavily glycosylated protein aberrantly expressed in PDAC and promotes tumorigenesis via an unknown mechanism. To assess this, we genetically knocked out (KO) MUC4 in PDAC cells that did not express and did express truncate...

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Publicado no:Cancer Lett
Main Authors: Sagar, Satish, Leiphrakpam, Pramila D., Thomas, Divya, McAndrews, Kyle L., Caffrey, Thomas C., Swanson, Benjamin J., Clausen, Henrik, Wandall, Hans H., Hollingsworth, Michael A., Radhakrishnan, Prakash
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7981252/
https://ncbi.nlm.nih.gov/pubmed/33485947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2021.01.015
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