An mTORC1-dependent switch orchestrates the transition between mouse spermatogonial stem cells and clones of progenitor spermatogonia

Spermatogonial stem cells (SSCs) sustain spermatogenesis by balancing self-renewal and initiation of differentiation to produce progenitor spermatogonia committed to forming sperm. To define the regulatory logic among SSCs and progenitors, we performed single-cell RNA velocity analyses and validated...

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Bibliographic Details
Published in:Cell Rep
Main Authors: Suzuki, Shinnosuke, McCarrey, John R., Hermann, Brian P.
Format: Artigo
Language:Inglês
Published: 2021
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7980622/
https://ncbi.nlm.nih.gov/pubmed/33596419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2021.108752
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