Aryl hydrocarbon receptor is essential for the pathogenesis of pulmonary arterial hypertension

Pulmonary arterial hypertension (PAH) is a devastating disease characterized by arteriopathy in the small to medium-sized distal pulmonary arteries, often accompanied by infiltration of inflammatory cells. Aryl hydrocarbon receptor (AHR), a nuclear receptor/transcription factor, detoxifies xenobioti...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Masaki, Takeshi, Okazawa, Makoto, Asano, Ryotaro, Inagaki, Tadakatsu, Ishibashi, Tomohiko, Yamagishi, Akiko, Umeki-Mizushima, Saori, Nishimura, Manami, Manabe, Yusuke, Ishibashi-Ueda, Hatsue, Shirai, Manabu, Tsuchimochi, Hirotsugu, Pearson, James T, Kumanogoh, Atsushi, Sakata, Yasushi, Ogo, Takeshi, Kishimoto, Tadamitsu, Nakaoka, Yoshikazu
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2021
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7980441/
https://ncbi.nlm.nih.gov/pubmed/33836606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2023899118
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