Type I interferon activation and endothelial dysfunction in caveolin-1 insufficiency-associated pulmonary arterial hypertension

Interferonopathies, interferon (IFN)-α/β therapy, and caveolin-1 (CAV1) loss-of-function have all been associated with pulmonary arterial hypertension (PAH). Here, CAV1-silenced primary human pulmonary artery endothelial cells (PAECs) were proliferative and hypermigratory, with reduced cytoskeletal...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Gairhe, Salina, Awad, Keytam S., Dougherty, Edward J., Ferreyra, Gabriela A., Wang, Shuibang, Yu, Zu-Xi, Takeda, Kazuyo, Demirkale, Cumhur Y., Torabi-Parizi, Parizad, Austin, Eric D., Elinoff, Jason M., Danner, Robert L.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2021
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7980434/
https://ncbi.nlm.nih.gov/pubmed/33836561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2010206118
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