Fibrotic Response to Neoadjuvant Therapy Predicts Survival in Pancreatic Cancer and is Measurable with Collagen-Targeted Molecular MRI

PURPOSE: To evaluate the prognostic value of post-treatment fibrosis in human PDAC patients, and to compare a type I collagen targeted MRI probe, CM-101, to the standard contrast agent, Gd-DOTA, for their abilities to identify FOLFIRINOX-induced fibrosis in a murine model of PDAC. EXPERIMENTAL DESIG...

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Veröffentlicht in:Clin Cancer Res
Hauptverfasser: Erstad, Derek J., Sojoodi, Mozhdeh, Taylor, Martin S., Jordan, Veronica Clavijo, Farrar, Christian T., Axtell, Andrea L., Rotile, Nicholas J., Jones, Chloe, Graham-O’Regan, Katherine A., Ferreira, Diego S., Michelakos, Theodoros, Kontos, Filippos, Chawla, Akhil, Li, Shen, Ghoshal, Sarani, Chen, Yin-Ching Iris, Arora, Gunisha, Humblet, Valerie, Deshpande, Vikram, Qadan, Motaz, Bardeesy, Nabeel, Ferrone, Cristina R., Lanuti, Michael, Tanabe, Kenneth K., Caravan, Peter, Fuchs, Bryan C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7980315/
https://ncbi.nlm.nih.gov/pubmed/32611647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-1359
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