Peripheral decarboxylase inhibitors paradoxically induce aromatic L-amino acid decarboxylase

Peripheral decarboxylase inhibitors (PDIs) prevent conversion of levodopa to dopamine in the blood by the enzyme aromatic L-amino acid decarboxylase (AADC). Alterations in enzyme activity may contribute to the required higher dosages of levodopa observed in many patients with Parkinson’s disease. We...

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Pubblicato in:NPJ Parkinsons Dis
Autori principali: van Rumund, Anouke, Pavelka, Lukas, Esselink, Rianne A. J., Geurtz, Ben P. M., Wevers, Ron A., Mollenhauer, Brit, Krüger, Rejko, Bloem, Bastiaan R., Verbeek, Marcel M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7979935/
https://ncbi.nlm.nih.gov/pubmed/33741988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41531-021-00172-z
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