Cerebellar Kv3.3 potassium channels activate TANK-binding kinase 1 to regulate trafficking of the cell survival protein Hax-1

Mutations in KCNC3, which encodes the Kv3.3 potassium channel, cause degeneration of the cerebellum, but exactly how the activity of an ion channel is linked to the survival of cerebellar neurons is not understood. Here, we report that Kv3.3 channels bind and stimulate Tank Binding Kinase 1 (TBK1),...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Zhang, Yalan, Varela, Luis, Szigeti-Buck, Klara, Williams, Adam, Stoiljkovic, Milan, Šestan-Peša, Matija, Henao-Mejia, Jorge, D’Acunzo, Pasquale, Levy, Efrat, Flavell, Richard A., Horvath, Tamas L., Kaczmarek, Leonard K.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7979925/
https://ncbi.nlm.nih.gov/pubmed/33741962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-22003-8
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