Repurposing dextromethorphan and metformin for treating nicotine-induced cancer by directly targeting CHRNA7 to inhibit JAK2/STAT3/SOX2 signaling

Smoking is one of the most impactful lifestyle-related risk factors in many cancer types including esophageal squamous cell carcinoma (ESCC). As the major component of tobacco and e-cigarettes, nicotine is not only responsible for addiction to smoking but also a carcinogen. Here we report that nicot...

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Pubblicato in:Oncogene
Autori principali: Wang, Lu, Du, Liang, Xiong, Xiao, Lin, Yusheng, Zhu, Jianlin, Yao, Zhimeng, Wang, Shuhong, Guo, Yi, Chen, Yuping, Geary, Kyla, Pan, Yunlong, Zhou, Fuyou, Gao, Shegan, Zhang, Dianzheng, Yeung, Sai-Ching Jim, Zhang, Hao
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7979537/
https://ncbi.nlm.nih.gov/pubmed/33603170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-021-01682-z
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