Ribonuclease 7-driven activation of ROS1 is a potential therapeutic target in hepatocellular carcinoma

BACKGROUND & AIMS: Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer with limited therapeutic options. Here, we investigated the mechanisms of HCC in response to ROS1-targeted therapy. METHODS: Recombinant RNases were purified, and the ligand-receptor relationship be...

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Detalhes bibliográficos
Publicado no:J Hepatol
Main Authors: Liu, Chunxiao, Zha, Zhengyu, Zhou, Chenhao, Chen, Yeh, Xia, Weiya, Wang, Ying-Nai, Lee, Heng-Huan, Yin, Yirui, Yan, Meisi, Chang, Chiung-Wen, Chan, Li-Chuan, Qiu, Yufan, Li, Hui, Li, Chia-Wei, Hsu, Jung-Mao, Hsu, Jennifer L., Wang, Shao-Chun, Ren, Ning, Hung, Mien-Chie
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7979498/
https://ncbi.nlm.nih.gov/pubmed/33031845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2020.09.030
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