Single-cell transcriptome analysis of the heterogeneous effects of differential expression of tumor PD-L1 on responding TCR-T cells

Rationale: TCR-T cell therapy plays a critical role in the treatment of malignant cancers. However, it is unclear how TCR-T cells are affected by PD-L1 molecule in the tumor environment. We performed an in-depth evaluation on how differential expressions of tumor PD-L1 can affect the functionality o...

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Bibliographische Detailangaben
Veröffentlicht in:Theranostics
Hauptverfasser: Ding, Renpeng, Liu, Shang, Wang, Shanshan, Chen, Huanyi, Wang, Fei, Xu, Qumiao, Zhu, Linnan, Dong, Xuan, Gu, Ying, Zhang, Xiuqing, Chao, Cheng-Chi, Gao, Qianqian
Format: Artigo
Sprache:Inglês
Veröffentlicht: Ivyspring International Publisher 2021
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7978322/
https://ncbi.nlm.nih.gov/pubmed/33754038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.55075
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