Thyroid hormone plus dual-specificity phosphatase-5 siRNA increases the number of cardiac muscle cells and improves left ventricular contractile function in chronic doxorubicin-injured hearts

Rationale: Doxorubicin is a widely used anticancer drug. However, its major side effect, cardiotoxicity, results from cardiomyocyte loss that causes left ventricle (LV) wall thinning, chronic LV dysfunction and heart failure. Cardiomyocyte number expansion by thyroid hormone (T3) during preadolescen...

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Detalhes bibliográficos
Publicado no:Theranostics
Main Authors: Tan, Lin, Bogush, Nikolay, Naqvi, Emmen, Calvert, John W., Graham, Robert M., Taylor, W. Robert, Naqvi, Nawazish, Husain, Ahsan
Formato: Artigo
Idioma:Inglês
Publicado em: Ivyspring International Publisher 2021
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7978295/
https://ncbi.nlm.nih.gov/pubmed/33754028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.57456
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