Human CD141(+) dendritic cells (cDC1) are impaired in patients with advanced melanoma but can be targeted to enhance anti-PD-1 in a humanized mouse model

BACKGROUND: The conventional type 1 dendritic cell subset (cDC1) is indispensable for tumor immune responses and the efficacy of immune checkpoint inhibitor (ICI) therapies in animal models but little is known about the role of the human CD141(+) DC cDC1 equivalent in patients with melanoma. METHODS...

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Veröffentlicht in:J Immunother Cancer
Hauptverfasser: Lee, Yoke Seng, O'Brien, Liam J, Walpole, Carina M, Pearson, Frances E, Leal-Rojas, Ingrid M, Masterman, Kelly-Anne, Atkinson, Victoria, Barbour, Andrew, Radford, Kristen J
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMJ Publishing Group 2021
Schlagworte:
Clinical/Translational Cancer Immunotherapy
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7978242/
https://ncbi.nlm.nih.gov/pubmed/33737342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2020-001963
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