Agonistic anti-CD40 overcomes T cell exhaustion induced by chronic myeloid cell IL-27 production in a pancreatic cancer preclinical model

Pancreatic cancer is a particularly lethal malignancy and resists immunotherapy. Here, using a preclinical pancreatic cancer murine model, we demonstrate a progressive decrease in IFNγ and Granzyme B and a concomitant increase in Tox and IL-10 in intratumoral tumor-specific T cells. Intratumoral mye...

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Bibliographic Details
Published in:J Immunol
Main Authors: Burrack, Adam L., Rollins, Meagan R., Spartz, Ellen J., Mesojednik, Taylor D., Schmiechen, Zoe C., Raynor, Jackson F., Wang, Iris, Kedl, Ross M., Stromnes, Ingunn M.
Format: Artigo
Language:Inglês
Published: 2021
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7977703/
https://ncbi.nlm.nih.gov/pubmed/33558374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.2000765
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