Intratumor heterogeneity of breast cancer detected by epialleles shows association with hypoxic microenvironment

Rationale: In breast cancer, high intratumor DNA methylation heterogeneity can lead to drug-resistant, metastasis and poor prognosis of tumors, which increases the complexity of cancer diagnosis and treatment. However, most studies are limited to average DNA methylation level of individual CpGs and...

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Bibliographische Detailangaben
Veröffentlicht in:Theranostics
Hauptverfasser: Wang, Yihan, Zhang, Yan, Huang, Yan, Chen, Chuangeng, Zhang, Xingda, Xing, Ying, Gu, Yue, Zhang, Mengyan, Cai, Li, Xu, Shouping, Sun, Baoqing
Format: Artigo
Sprache:Inglês
Veröffentlicht: Ivyspring International Publisher 2021
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7977462/
https://ncbi.nlm.nih.gov/pubmed/33754068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.53737
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