Tamoxifen suppresses brain metastasis of estrogen receptor-deficient breast cancer by skewing microglia polarization and enhancing their immune functions

BACKGROUND: Brain metastasis of breast cancer exhibits exceedingly poor prognosis, and both triple negative (TN) and Her2(+) subtypes have the highest incidence of brain metastasis. Although estrogen blockers are considered to be ineffective for their treatment, recent evidence indicates that estrog...

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Foilsithe in:Breast Cancer Res
Main Authors: Wu, Shih-Ying, Sharma, Sambad, Wu, Kerui, Tyagi, Abhishek, Zhao, Dan, Deshpande, Ravindra Pramod, Watabe, Kounosuke
Formáid: Artigo
Teanga:Inglês
Foilsithe: BioMed Central 2021
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7977276/
https://ncbi.nlm.nih.gov/pubmed/33736709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13058-021-01412-z
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