Astrocyte-specific hypoxia-inducible factor 1 (HIF-1) does not disrupt the endothelial barrier during hypoxia in vitro

BACKGROUND: Astrocytes (AC) are essential for brain homeostasis. Much data suggests that AC support and protect the vascular endothelium, but increasing evidence indicates that during injury conditions they may lose their supportive role resulting in endothelial cell activation and BBB disturbance....

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Bibliografiske detaljer
Udgivet i:Fluids Barriers CNS
Main Authors: Baumann, Julia, Tsao, Chih-Chieh, Huang, Sheng-Fu, Gassmann, Max, Ogunshola, Omolara O.
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2021
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7977259/
https://ncbi.nlm.nih.gov/pubmed/33736658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12987-021-00247-2
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