Targeting the AnxA1/Fpr2/ALX pathway regulates neutrophil function, promoting thromboinflammation resolution in sickle cell disease

Neutrophils play a crucial role in the intertwined processes of thrombosis and inflammation. An altered neutrophil phenotype may contribute to inadequate resolution, which is known to be a major pathophysiological contributor of thromboinflammatory conditions such as sickle cell disease (SCD). The e...

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Udgivet i:Blood
Main Authors: Ansari, Junaid, Senchenkova, Elena Y., Vital, Shantel A., Al-Yafeai, Zaki, Kaur, Gaganpreet, Sparkenbaugh, Erica M., Orr, A. Wayne, Pawlinski, Rafal, Hebbel, Robert P., Granger, D. Neil, Kubes, Paul, Gavins, Felicity N. E.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2021
Fag:
Vascular Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7976506/
https://ncbi.nlm.nih.gov/pubmed/33512489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2020009166
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