Hepatic stellate cell–specific knockout of transcriptional intermediary factor 1γ aggravates liver fibrosis

Transforming growth factor β (TGFβ) is a crucial factor in fibrosis, and transcriptional intermediary factor 1γ (TIF1γ) is a negative regulator of the TGFβ pathway; however, its role in liver fibrosis is unknown. In this study, mesenchymal stem cells derived from human embryonic stem cells (hE-MSCs)...

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Foilsithe in:J Exp Med
Main Authors: Lee, Eun Ju, Hwang, Injoo, Lee, Ji Yeon, Park, Jong Nam, Kim, Keun Cheon, Kim, Irene, Moon, Dodam, Park, Hyomin, Lee, Seo-Yeon, Kim, Hong Sug, Jun, Dae Won, Park, Sung-Hye, Kim, Hyo-Soo
Formáid: Artigo
Teanga:Inglês
Foilsithe: Rockefeller University Press 2020
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7971140/
https://ncbi.nlm.nih.gov/pubmed/32267915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20190402
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