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Asymmetric Catalysis Upon Helically Chiral Loratadine Analogs Unveils Enantiomer-Dependent Antihistamine Activity
Analogs of the conformationally dynamic Claritin(®) (loratadine) and Clarinex(®) (desloratadine) scaffolds have been enantio- and chemoselectively N-oxidized using an aspartic acid containing peptide catalyst to afford stable, helically chiral products in up to >99:1 er. The conformational dynami...
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| Publicado no: | J Am Chem Soc |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7970157/ https://ncbi.nlm.nih.gov/pubmed/32579347 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.0c03904 |
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