Combination With Tomatidine Improves the Potency of Posaconazole Against Trypanosoma cruzi

Azoles such as posaconazole (Posa) are highly potent against Trypanosoma cruzi. However, when tested in chronic Chagas disease patients, a high rate of relapse after Posa treatment was observed. It appears that inhibition of T. cruzi cytochrome CYP51, the target of azoles, does not deliver sterile c...

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Detalhes bibliográficos
Publicado no:Front Cell Infect Microbiol
Main Authors: Rocha-Hasler, Marianne, de Oliveira, Gabriel Melo, da Gama, Aline Nefertiti, Fiuza, Ludmila Ferreira de Almeida, Fesser, Anna Frieda, Cal, Monica, Rocchetti, Romina, Peres, Raiza Brandão, Guan, Xue Li, Kaiser, Marcel, Soeiro, Maria de Nazaré Correia, Mäser, Pascal
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Cellular and Infection Microbiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7970121/
https://ncbi.nlm.nih.gov/pubmed/33747979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcimb.2021.617917
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