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MMB-FOXM1-driven premature mitosis is required for CHK1 inhibitor sensitivity
To identify genes whose loss confers resistance to CHK1 inhibitors, we perform genome-wide CRISPR-Cas9 screens in non-small-cell lung cancer (NSCLC) cell lines treated with the CHK1 inhibitor prexasertib (CHK1i). Five of the top six hits of the screens, MYBL2 (B-MYB), LIN54, FOXM1, cyclin A2 (CCNA2)...
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| Foilsithe in: | Cell Rep |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
2021
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7970065/ https://ncbi.nlm.nih.gov/pubmed/33657372 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2021.108808 |
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