CHK1 Inhibitor Blocks Phosphorylation of FAM122A and Promotes Replication Stress

While effective anti-cancer drugs targeting the CHK1 kinase are advancing in the clinic, drug resistance is rapidly emerging. Here, we demonstrate that CRISPR-mediated knockout of the little-known gene FAM122A confers cellular resistance to CHK1 inhibitors and cross-resistance to ATR inhibitors. Kno...

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Li, Feng, Kozono, David, Deraska, Peter, Branigan, Timothy, Dunn, Connor, Zheng, Xiao-Feng, Parmar, Kalindi, Nguyen, Huy, DeCaprio, James, Shapiro, Geoffrey I., Chowdhury, Dipanjan, D’Andrea, Alan D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7761918/
https://ncbi.nlm.nih.gov/pubmed/33108758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2020.10.008
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