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CHK1 Inhibitor Blocks Phosphorylation of FAM122A and Promotes Replication Stress
While effective anti-cancer drugs targeting the CHK1 kinase are advancing in the clinic, drug resistance is rapidly emerging. Here, we demonstrate that CRISPR-mediated knockout of the little-known gene FAM122A confers cellular resistance to CHK1 inhibitors and cross-resistance to ATR inhibitors. Kno...
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| 出版年: | Mol Cell |
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| 主要な著者: | , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2020
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7761918/ https://ncbi.nlm.nih.gov/pubmed/33108758 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2020.10.008 |
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