Splicing factor USP39 promotes ovarian cancer malignancy through maintaining efficient splicing of oncogenic HMGA2

Aberrant expression of splicing factors was found to promote tumorigenesis and the development of human malignant tumors. Nevertheless, the underlying mechanisms and functional relevance remain elusive. We here show that USP39, a component of the spliceosome, is frequently overexpressed in high-grad...

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Vydáno v:Cell Death Dis
Hlavní autoři: Wang, Shourong, Wang, Zixiang, Li, Jieyin, Qin, Junchao, Song, Jianping, Li, Yingwei, Zhao, Ling, Zhang, Xiyu, Guo, Haiyang, Shao, Changshun, Kong, Beihua, Liu, Zhaojian
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7969951/
https://ncbi.nlm.nih.gov/pubmed/33731694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-021-03581-3
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