Activation of GPR37 in macrophages confers protection against infection-induced sepsis and pain-like behaviour in mice

GPR37 was discovered more than two decades ago, but its biological functions remain poorly understood. Here we report a protective role of GPR37 in multiple models of infection and sepsis. Mice lacking Gpr37 exhibited increased death and/or hypothermia following challenge by lipopolysaccharide (LPS)...

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Publicat a:Nat Commun
Autors principals: Bang, Sangsu, Donnelly, Christopher R., Luo, Xin, Toro-Moreno, Maria, Tao, Xueshu, Wang, Zilong, Chandra, Sharat, Bortsov, Andrey V., Derbyshire, Emily R., Ji, Ru-Rong
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7969930/
https://ncbi.nlm.nih.gov/pubmed/33731716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21940-8
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