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Activation of GPR37 in macrophages confers protection against infection-induced sepsis and pain-like behaviour in mice
GPR37 was discovered more than two decades ago, but its biological functions remain poorly understood. Here we report a protective role of GPR37 in multiple models of infection and sepsis. Mice lacking Gpr37 exhibited increased death and/or hypothermia following challenge by lipopolysaccharide (LPS)...
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| 出版年: | Nat Commun |
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| 主要な著者: | , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group UK
2021
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7969930/ https://ncbi.nlm.nih.gov/pubmed/33731716 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21940-8 |
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