A conserved immunogenic and vulnerable site on the coronavirus spike protein delineated by cross-reactive monoclonal antibodies

The coronavirus spike glycoprotein, located on the virion surface, is the key mediator of cell entry and the focus for development of protective antibodies and vaccines. Structural studies show exposed sites on the spike trimer that might be targeted by antibodies with cross-species specificity. Her...

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Pubblicato in:Nat Commun
Autori principali: Wang, Chunyan, van Haperen, Rien, Gutiérrez-Álvarez, Javier, Li, Wentao, Okba, Nisreen M. A., Albulescu, Irina, Widjaja, Ivy, van Dieren, Brenda, Fernandez-Delgado, Raul, Sola, Isabel, Hurdiss, Daniel L., Daramola, Olalekan, Grosveld, Frank, van Kuppeveld, Frank J. M., Haagmans, Bart L., Enjuanes, Luis, Drabek, Dubravka, Bosch, Berend-Jan
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7969777/
https://ncbi.nlm.nih.gov/pubmed/33731724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21968-w
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