A conserved immunogenic and vulnerable site on the coronavirus spike protein delineated by cross-reactive monoclonal antibodies

The coronavirus spike glycoprotein, located on the virion surface, is the key mediator of cell entry and the focus for development of protective antibodies and vaccines. Structural studies show exposed sites on the spike trimer that might be targeted by antibodies with cross-species specificity. Her...

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Publié dans:Nat Commun
Auteurs principaux: Wang, Chunyan, van Haperen, Rien, Gutiérrez-Álvarez, Javier, Li, Wentao, Okba, Nisreen M. A., Albulescu, Irina, Widjaja, Ivy, van Dieren, Brenda, Fernandez-Delgado, Raul, Sola, Isabel, Hurdiss, Daniel L., Daramola, Olalekan, Grosveld, Frank, van Kuppeveld, Frank J. M., Haagmans, Bart L., Enjuanes, Luis, Drabek, Dubravka, Bosch, Berend-Jan
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2021
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7969777/
https://ncbi.nlm.nih.gov/pubmed/33731724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21968-w
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