Mycobacterium tuberculosis RipA Dampens TLR4-Mediated Host Protective Response Using a Multi-Pronged Approach Involving Autophagy, Apoptosis, Metabolic Repurposing, and Immune Modulation

Reductive evolution has endowed Mycobacterium tuberculosis (M. tb) with moonlighting in protein functions. We demonstrate that RipA (Rv1477), a peptidoglycan hydrolase, activates the NFκB signaling pathway and elicits the production of pro-inflammatory cytokines, TNF-α, IL-6, and IL-12, through the...

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Detalles Bibliográficos
Publicado en:Front Immunol
Main Authors: Shariq, Mohd, Quadir, Neha, Sharma, Neha, Singh, Jasdeep, Sheikh, Javaid A., Khubaib, Mohd, Hasnain, Seyed E., Ehtesham, Nasreen Z.
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2021
Assuntos:
Immunology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7969667/
https://ncbi.nlm.nih.gov/pubmed/33746976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.636644
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