Mycobacterium tuberculosis Protein PE6 (Rv0335c), a Novel TLR4 Agonist, Evokes an Inflammatory Response and Modulates the Cell Death Pathways in Macrophages to Enhance Intracellular Survival

Mycobacterium tuberculosis (M. tb) is an intracellular pathogen that exploits moonlighting functions of its proteins to interfere with host cell functions. PE/PPE proteins utilize host inflammatory signaling and cell death pathways to promote pathogenesis. We report that M. tb PE6 protein (Rv0335c)...

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發表在:Front Immunol
Main Authors: Sharma, Neha, Shariq, Mohd, Quadir, Neha, Singh, Jasdeep, Sheikh, Javaid A., Hasnain, Seyed E., Ehtesham, Nasreen Z.
格式: Artigo
語言:Inglês
出版: Frontiers Media S.A. 2021
主題:
Immunology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC8311496/
https://ncbi.nlm.nih.gov/pubmed/34322125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.696491
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