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Target-Mediated Drug Disposition (TMDD) – a Class Effect of Soluble Epoxide Hydrolase (sEH) Inhibitors

Pharmacological target-mediated drug disposition (TMDD) represents a special source of nonlinear pharmacokinetics, and its occurrence in large-molecule compounds has been well recognized because numerous protein drugs have been reported to have TMDD due to specific binding to their pharmacological t...

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Publicat a:J Clin Pharmacol
Autors principals: An, Guohua, Lee, Kin Sing Stephen, Yang, Jun, Hammock, Bruce D.
Format: Artigo
Idioma:Inglês
Publicat: 2020
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7969377/
https://ncbi.nlm.nih.gov/pubmed/33078430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcph.1763
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