Tandem RNA binding sites induce self-association of the stress granule marker protein TIA-1

TIA-1 is an RNA-binding protein that sequesters target RNA into stress granules under conditions of cellular stress. Promotion of stress granule formation by TIA-1 depends upon self-association of its prion-like domain that facilitates liquid-liquid phase separation and is thought to be enhanced via...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Loughlin, Fionna E, West, Danella L, Gunzburg, Menachem J, Waris, Saboora, Crawford, Simon A, Wilce, Matthew C J, Wilce, Jacqueline A
Format: Artigo
Language:Inglês
Published: Oxford University Press 2021
Subjects:
NAR Breakthrough Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7969032/
https://ncbi.nlm.nih.gov/pubmed/33621982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkab080
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