Hsp70 acts as a fine-switch that controls E3 ligase CHIP-mediated TAp63 and ΔNp63 ubiquitination and degradation

The major clinical problem in human cancer is metastasis. Metastases are the cause of 90% of human cancer deaths. TAp63 is a critical suppressor of tumorigenesis and metastasis. ΔNp63 acts as a dominant-negative inhibitor to block the function of p53 and TAp63. Although several ubiquitin E3 ligases...

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Bibliografiske detaljer
Udgivet i:Nucleic Acids Res
Main Authors: Wu, H Helena, Wang, Benfan, Armstrong, Stephen R, Abuetabh, Yasser, Leng, Sarah, Roa, Wilson H Y, Atfi, Azeddine, Marchese, Adriano, Wilson, Beverly, Sergi, Consolato, Flores, Elsa R, Eisenstat, David D, Leng, Roger P
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2021
Fag:
Molecular Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7969027/
https://ncbi.nlm.nih.gov/pubmed/33619536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkab081
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