Fra-1 regulates its target genes via binding to remote enhancers without exerting major control on chromatin architecture in triple negative breast cancers

The ubiquitous family of dimeric transcription factors AP-1 is made up of Fos and Jun family proteins. It has long been thought to operate principally at gene promoters and how it controls transcription is still ill-understood. The Fos family protein Fra-1 is overexpressed in triple negative breast...

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Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Bejjani, Fabienne, Tolza, Claire, Boulanger, Mathias, Downes, Damien, Romero, Raphaël, Maqbool, Muhammad Ahmad, Zine El Aabidine, Amal, Andrau, Jean-Christophe, Lebre, Sophie, Brehelin, Laurent, Parrinello, Hughes, Rohmer, Marine, Kaoma, Tony, Vallar, Laurent, Hughes, Jim R, Zibara, Kazem, Lecellier, Charles-Henri, Piechaczyk, Marc, Jariel-Encontre, Isabelle
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2021
Schlagworte:
Gene regulation, Chromatin and Epigenetics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7968996/
https://ncbi.nlm.nih.gov/pubmed/33533919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkab053
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