Basis of specificity for a conserved and promiscuous chromatin remodeling protein

Eukaryotic genomes are organized dynamically through the repositioning of nucleosomes. Isw2 is an enzyme that has been previously defined as a genome-wide, nonspecific nucleosome spacing factor. Here, we show that Isw2 instead acts as an obligately targeted nucleosome remodeler in vivo through physi...

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Pubblicato in:eLife
Autori principali: Donovan, Drake A, Crandall, Johnathan G, Truong, Vi N, Vaaler, Abigail L, Bailey, Thomas B, Dinwiddie, Devin, Banks, Orion GB, McKnight, Laura E, McKnight, Jeffrey N
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2021
Soggetti:
Biochemistry and Chemical Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7968928/
https://ncbi.nlm.nih.gov/pubmed/33576335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.64061
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