GREB1: An evolutionarily conserved protein with a glycosyltransferase domain links ERα glycosylation and stability to cancer

What covalent modifications control the temporal ubiquitination of ERα and hence the duration of its transcriptional activity remain poorly understood. We show that GREB1, an ERα-inducible enzyme, catalyzes O-GlcNAcylation of ERα at residues T553/S554, which stabilizes ERα protein by inhibiting asso...

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Publicat a:Sci Adv
Autors principals: Shin, Eun Myoung, Huynh, Vinh Thang, Neja, Sultan Abda, Liu, Chia Yi, Raju, Anandhkumar, Tan, Kelly, Tan, Nguan Soon, Gunaratne, Jayantha, Bi, Xuezhi, Iyer, Lakshminarayan M., Aravind, L., Tergaonkar, Vinay
Format: Artigo
Idioma:Inglês
Publicat: American Association for the Advancement of Science 2021
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7968844/
https://ncbi.nlm.nih.gov/pubmed/33731348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abe2470
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