Sulfasalazine modifies metabolic profiles and enhances cisplatin chemosensitivity on cholangiocarcinoma cells in in vitro and in vivo models

BACKGROUND: Sulfasalazine (SSZ) is widely known as an xCT inhibitor suppressing CD44v9-expressed cancer stem-like cells (CSCs) being related to redox regulation. Cholangiocarcinoma (CCA) has a high recurrence rate and no effective chemotherapy. A recent report revealed high levels of CD44v9-positive...

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Publicat a:Cancer Metab
Autors principals: Thanee, Malinee, Padthaisong, Sureerat, Suksawat, Manida, Dokduang, Hasaya, Phetcharaburanin, Jutarop, Klanrit, Poramate, Titapun, Attapol, Namwat, Nisana, Wangwiwatsin, Arporn, Sa-ngiamwibool, Prakasit, Khuntikeo, Narong, Saya, Hideyuki, Loilome, Watcharin
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2021
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7968252/
https://ncbi.nlm.nih.gov/pubmed/33726850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40170-021-00249-6
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