Common variants at 21q22.3 locus influence MX1 and TMPRSS2 gene expression and susceptibility to severe COVID-19

The established risk factors of coronavirus disease 2019 (COVID-19) are advanced age, male sex, and comorbidities, but they do not fully explain the wide spectrum of disease manifestations. Genetic factors implicated in the host antiviral response provide for novel insights into its pathogenesis. We...

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Bibliografiska uppgifter
I publikationen:iScience
Huvudupphovsmän: Andolfo, Immacolata, Russo, Roberta, Lasorsa, Vito Alessandro, Cantalupo, Sueva, Rosato, Barbara Eleni, Bonfiglio, Ferdinando, Frisso, Giulia, Abete, Pasquale, Cassese, Gian Marco, Servillo, Giuseppe, Esposito, Gabriella, Gentile, Ivan, Piscopo, Carmelo, Villani, Romolo, Fiorentino, Giuseppe, Cerino, Pellegrino, Buonerba, Carlo, Pierri, Biancamaria, Zollo, Massimo, Iolascon, Achille, Capasso, Mario
Materialtyp: Artigo
Språk:Inglês
Publicerad: Elsevier 2021
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7968217/
https://ncbi.nlm.nih.gov/pubmed/33748697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2021.102322
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